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Antecedentes: El impacto de la profilaxis pre-exposición (PrEP) sobre la salud mental, así como en la satisfacción sexual y con la vida son aún desconocidas. Método: Analizamos 114 participantes VIH negativos de España con rango de edad [19-58 años], donde el 60,5% eran usuarios de PrEP (n = 69) y el 39,5% no (n = 45). Completaron cinco tests sobre la satisfacción sexual y con la vida, la depresión y la ansiedad. Realizamos correlaciones y análisis de regresión múltiple. Resultados: El uso de PrEP correlacionó con un incremento de la satisfacción sexual y con la vida. Mostraron una correlación negativa en depresión y ansiedad que no se observó en los no consumidores de PrEP. Los usuarios de PrEP más jóvenes mostraban puntuaciones más altas en ansiedad y más bajas en depresión que los de mayor edad. Los análisis de regresión jerárquica mostraron que el número de parejas sexuales fue un predictor importante en el grupo de PrEP para la NSSS. Conclusión: La correlación indirecta entre la satisfacción sexual, la depresión y los síntomas de ansiedad en los usuarios de PrEP, podría ser la base de los beneficios que la PrEP puede ofrecer a la vida sexual de los pacientes.
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