Abstract
Role of caudate nucleus histaminic receptors H1 on cognitive impairment and activity produced by inescapable shocks in rats.- The antihistaminic activity of some tricyclic antidepressants is well known. Some authors associate the sedative power of these drugs with their affinity through of H1 receptors. In the present research, using a animal depression model, the effects produced by the microinyection of 2-Thiazolylethylamine and astemizol (selective agoniste and antagoniste for H1 receptors) into the caudate nucleus are presented. Without rejecting the possibility that the antagoniste have a certain sedative influence, the most clear effect was the cognitive impairment of the experimental animals produced by the antagoniste. This results introduce some doubts about the activity areas of some antidepressive drugs currently used.
