Abstract
Although some studies indicate that sulpiride (an atypical neuroleptic drug) increases body weight in female rodents after long-term administration, this action is less clear in males. In this study, we examined the effect of three doses of sulpiride (40, 60 or 80 mg/kg, ip) or physiological saline, chronically administered during 9 consecutive days, on body weight in the OF.1 strain of adult male mice. All animals were housed in transparent plastic cages during four weeks (non-drug period) and weighted weekly. During the drug period, sulpiride was administered once daily for 9 days and body weights measured. Results showed that sulpiride did not vary body weight after chronic administration, suggesting that the action of some neuroleptics on body weight might be a sex-dependent phenomenon.
