Abstract
Characteristics and treatment of treatment-resistant obsessive disorder. This article describes the clinical profile referring obsessive patients without manifiest compulsions as a subtype of treatment-resistant obsessive-compulsive disorder (OCD), with poor response to effective treatment approaches (cognitive-behavioral therapy and pharmacotherapy). There are no clear criteria when defining the concept of treatment refractory patients. A number of factors such as partial response to pharmacotherapy of frist choice (clomipramine and fluvoxamine) and to observe a small reduction in the symptomps with intensive trials of exposure and response prevention therapy (of at least the 65%) are considered posible causes of treatment-resistant disorder. The neutralization of obsessive thoughts is considered as a key element associated to obsessive disorder wich determines the refractoriness to the treatment. Revising the therapies used with resistant obsessive disorder we find three prevailing approaches: behavioural therapy, cognitive therapy and medical therapy. It is suggested that future clinical research should focus on this refractory group.
