Abstract
Functions and therapeutic potential of nitric oxide in Central Nervous System. Since NO was found in the nervous system, it has been described that NO activity is necessary for the adequate functioning of multiple processes such as learning and memory, neurogenesis and synaptic plasticity, neurohormonal control and circadian rhythmicity. A dysfunction of NO production are underlying to oxidative stress and excitotoxycity, and consequently to neurodegenerative diseases. Moreover, recently, alterations in NO amount have related to psychopathological disorders. The therapeutical approach using NO inhibitors or donors is a promising line, although it is still at preclinical level research. The present work reviews the more relevant data of central nervous system NO functioning.
