Keywords
GISTs
GISTs variante fusocelular
Kit (CD117) gastrointestinal stromal tumors
GISTs
GIST spindle cell type
Kit (CD117)
How to Cite
Abstract
Gastrointestinal stromal tumors are an uncommon cause of gastrointestinal bleeding. Among them those located in the jejunum represent 0,1%-3% of all gastrointestinal neoplasms. Gastrointestinal stromal tumors are potentially malignant. We report a rare cause of recurrent upper gastrointestinal bleeding in a 36-year-old male patient who presented to the emergency room with upper gastrointestinal bleeding and a palpable mass in the abdomen. Laparotomy revealed a mass in jejunum. Pathology reports a spindle cell gastrointestinal stromal tumor with potential malignant behavior. The patient is on imatinib treatment, free of recurrences. Aspects concerning morphology, immunohistochemistry and differential diagnosis of gastrointestinal stromal tumors are reviewed.
References
Yang M-L, Wang J-C, Zou W en-B, Yao DK. Clinicopathological characteristics and prognostic factors of gastrointestinal stromal tumors in Chinese patients. Oncol Lett. 2018;16(4):4905–14. https://doi.org/10.3892/ol.2018.9320
Mohamed A, Qureshi T Al, Rakha SM. Giant gastrointestinal stromal tumors of the stomach successfully treated with laparoscopic resection : Case report and literature review. Cureus. 2021;13(2):e13584. https://doi.org/10.7759/cureus.13584
Singhal T, Doddi S, Leake T, Parsi S, Hussain A, Chandra A, et al. Upper gastrointestinal bleeding due to gastric stromal tumour : a case report. Cases J. 2010;3:58.
https://doi.org/10.1186/1757-1626-3-58
Keawmanee P, Kasetsermwiriya W, Sukhvibul P, Techapongsatorn S, Sirivongs N, Srimontayamas S. The long-term outcome of gastrointestinal stromal tumors treatment. Japanese J Gastroenterol Res. 2021;1(4):1016. https://doi.org/10.13140/RG.2.2.17136.38403
Mohamed AA, Zahrani SM Al, Mohamed SA, Qureshi AS. Massive gastrointestinal haemorrhage unusual presentation of gastrointestinal stromal tumors of the jejunum : Case report and literature review. Cureus. 2021;13(4):e14266. https://doi.org/10.7759/cureus.14266
Liu H, Santanello A, Jimenez M, Kumthekar N. Jejunal gastrointestinal stromal tumor (GIST) as a rare cause of GI bleed : A case report. Cureus. 2022;14(4):e24272.
https://doi.org/10.7759/cureus.24272
Foo WC, Liegl-atzwanger B, Lazar AJ. Pathology of gastrointestinal stromal tumors. Clin Med Insights Pathol. 2012;5:23–33. https://doi.org/10.4137/CPath.S9689
Nishida T, Yoshinaga S, Takahashi T, Naito Y. Recent progress and challenges in the diagnosis and treatment of gastrointestinal stromal tumors. Cancers (Basel). 2021;13(13):3158. https://doi.org/10.3390/cancers13133158
Joensuu H. Risk stratification of patients diagnosed with gastrointestinal stromal tumor. Hum Pathol. 2008;39(10):1411–19. https://doi.org/10.1016/j.humpath.2008.06.025
Charville GW, Longacre TA. Surgical pathology of gastrointestinal stromal tumors : Practical implications of morphologic and molecular heterogeneity for precision medicine. Adv Anat Pathol. 2017;24(6):336–53.https://doi.org/10.1097/PAP.0000000000000166
Miettinen M, Majidi M, Lasota J. Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review. Eur J Cancer. 2002;38 Suppl 5:S39–51.https://doi.org/10.1016/s0959-8049(02)80602-5
Liu Q, Kong F, Zhou J, Dong M, Dong Q. Management of hemorrhage in gastrointestinal stromal tumors : a review. Cancer Manag Res. 2018;10:735–43.
https://doi.org/10.2147/CMAR.S159689
Liegl B, Hornick JL, Lazar AJF. Contemporary pathology of gastrointestinal stromal tumors. Hematol Oncol Clin North Am. 2009;23(1):49–68,vii–viii. https://doi.org/10.1016/j.hoc.2008.12.002
Miettinen M, Makhlouf H, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the jejunum and ileum: a clinicopathologic, immunohistochemical, and molecular genetic study of 906 cases before imatinib with long-term follow-up. Am J Surg Pathol. 2006;30(4):477–89. https://doi.org/10.1097/00000478-200604000-00008