Abstract
Systematic reviews (SR) and meta-analyses (MA) are essential research methodologies for the rigorous accumulation of knowledge in any empirical science. While MA enable more robust conclusions regarding the question of interest, the necessary conditions for their implementation are not always met. In such cases, SR can be conducted as an alternative. This tutorial examines the key similarities and differences between SR and MA, with a focus on the methodological processes involved in conducting an SR without MA. The phases discussed include formulation of the research question, definition of inclusion and exclusion criteria, literature search, data extraction, risk of bias assessment, outcome measurement, synthesis methods, and report writing. Special attention is given to two core features that distinguish SR from MA: the measurement of study outcomes (e.g., effect sizes, probability levels, direction of effects) and quantitative synthesis methods alternative to those typically employed in MA. An example is used throughout to illustrate each phase of the SR process. Finally, the tutorial discusses on the strengths and limitations of SR in comparison to MA.
References
Boon, M. H., y Thomson, H. (2021). The effect direction plot revisited: Application of the 2019 Cochrane Handbook guidance on alternative synthesis methods. Research Synthesis Methods, 12, 29-33. https://doi.org/10.1002/jrsm.1458
Booth, A., Sutton, A., y Papaioannou, D. (2016). Systematic approaches to a successful literature review (2ª ed.). Sage.
Borenstein, M., Hedges, L. V., Higgins, J. P. T., y Rothstein, H. R. (2021). Introduction to meta-analysis (2ª ed.). Wiley.
Botella, J., y Caperos, J. M. (2019). Metodología de Investigación en Psicología General Sanitaria. Síntesis.
Botella, J., y Sánchez-Meca, J. (2015). Meta-análisis en ciencias sociales y de la salud. Síntesis.
Campbell, M., Katikireddi, S. V., Sowden, A., y Thomson, H. (2019). Lack of transparency in reporting narrative synthesis of quantitative data: A methodological assessment of systematic reviews. Journal of Clinical Epidemiology, 105, 1-9. https://doi.org/10.1016/j.jclinepi.2018.08.019
Campbell, M., McKenzie, J. E., Sowden, A., Katikireddi, S. V., Brennan, S. E., Ellis, S., Hartmann-Boyce, J., Ryan, R., Shepperd, S., Thomas, J., Welch, V., y Thomson, H. (2020). Synthesis without meta-analysis (SWiM) in systematic reviews: Reporting guideline. British Medical Journal, 368, l6890. http://dx.doi.org/10.1136/bmj.l6890
Cook, D. A., y West, C. P. (2012). Conducting systematic reviews in medical education: a stepwise approach. Medical Education, 46, 943–952. https://doi.org/10.1111/j.1365-2923.2012.04328.x
Cooper, H. (2016). Research synthesis: A step-by-step approach (5ª ed.). Sage.
Cooper, H., Hedges, L. V., y Valentine, J. F. (Eds). (2019). The handbook of research synthesis and meta-analysis (3ª Ed.). Rusell Sage Foundation.
Cumpston, M. S., Brennan, S. E., Ryan, R., y McKenzie, J. E. (2023). Synthesis methods other than meta-analysis were commonly used but seldom specified: survey of systematic reviews. Journal of Clinical Epidemiology, 156, 42-52. https://doi.org/10.1016/j.jclinepi.2023.02.003
Garritty, C., Nussbaumer-Streit, B., Hamel, C., Devane, D., y Cochrane Rapid Reviews Methods Group (2025). Rapid reviews methods series: assessing the appropriateness of conducting a rapid review. BMJ Evidence-Based Medicine, 30(1), 55–60. https://doi.org/10.1136/bmjebm-2023-112722
Grant, M. J., y Booth, A. (2009). A typology of reviews: an analysis of 14 review types and associated methodologies. Health Information and Libraries Journal, 26, 91–108. https://doi.org/ 10.1111/j.1471-1842.2009.00848.x
Head, M. L., Holman, L, Lanfear, R., Kahn, A.T., y Jennions, M. D. (2015). The extent and consequences of P-Hacking in Science. PLoS Biology, 13(3), e1002106. https://doi.org/10.1371/journal.pbio.1002106
Higgins, J. P. T., Savović, J., Page, M. J., Elbers, R. G., y Sterne, J. A. C. (2024). Chapter 8: Assessing risk of bias in a randomized trial. En J. P. T. Higgins, J. Thomas, J. Chandler, M. Cumpston, T. Li, M. J. Page, y V. A. Welch (Eds.), Cochrane handbook for systematic reviews of interventions (Vers. 6.5). Cochrane Collaboration. https://doi.org/10.1002/9781119536604.ch8
Higgins, J. P. T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J., y Welch, V. A. (Eds) (2024). Cochrane handbook for systematic reviews of interventions (vers. 6.5). The Cochrane Collaboration. https://doi.org/10.1002/9781119536604
Ioannidis, J. P., Caplan, A. L., y Dal-Ré, R. (2017). Outcome reporting bias in clinical trials: why monitoring matters. British Medical Journal, 356, j408. https://doi.org/10.1136/bmj.j408
Ioannidis, J. P., Patsopoulos, N., y Rothstein, H. (2008). Reasons or excuses for avoiding meta-analysis in forest plots. British Medical Journal, 336(7658), 1413-1415. https://doi.org/10.1136/bmj.a117
López-López, J. A., Rubio-Aparicio, M., y Sánchez-Meca, J. (2022). Overview of reviews: Concept and development. Psicothema, 34, 175-181. https://doi.org/10.7334/psicothema2021.586
Lubbe, W., ten Ham-Baloyi, W., y Smit, K. (2020). The integrative literature review as a research method: A demonstration review of research on neurodevelopmental supportive care in preterm infants. Journal of Neonatal Nursing, 26, 308-315. https://doi.org/10.1016/j.jnn.2020.04.006
McKenzie, J. E., y Brennan, S. E. (2021). Synthesizing and presenting findings using other methods. En J. P. T. Higgins, J. Thomas, J. Chandler, M. Cumpston, T. Li, M. J. Page, y V. A. Welch (Eds.), Cochrane handbook for systematic reviews of interventions (2ª ed., pp. 321-347). Wiley.
Munn, Z., Pollock, D., Khalil, H., Alexander, L., Mclnerney, P., Godfrey, C. M., Peters, M., y Tricco, A. C. (2022). What are scoping reviews? Providing a formal definition of scoping reviews as a type of evidence synthesis. JBI Evidence Synthesis, 20(4), 950–952. https://doi.org/10.11124/JBIES-21-00483
Murphy, K. R., y Aguinis, H. (2019). HARKing: How badly can cherry-picking and question trolling produce bias in published results? Journal of Business and Psychology, 34, 1-17. https://doi.org/10.1371/journal.pbio.1002106
Ogilvie, D., Fayter, D., Petticrew, M., Sowden, A., Thomas, S., Whitehead, M., y Worthy, G. (2008). The harvest plot: a method for synthesising evidence about the differential effects of interventions. BMC Medical Research Methodology, 8(8). https://doi.org/10.1186/1471-2288-8-8
Open Science Collaboration (2015). Estimating the reproducibility of psychological science. Science, 349(6251), aac4716. https://doi.org/10.1126/science.aac4716
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., McGuinness, L. A., … Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting. British Medical Journal, 372, n71. http://dx.doi.org/10.1136/bmj.n160
Pardo, A., Ruiz, M. A., y San Martín, R. (2015). Análisis de datos en ciencias sociales y de la salud I (2ª ed.). Síntesis.
Plakkal, N. (2023). How to write a systematic review without meta‑analysis. International Journal of Advanced Medical and Health Research, 10, 119-23. https://doi.org/10.4103/ijamr.ijamr_296_23
Popay, J., Roberts, H., Sowden, A., Petticrew, M., Arai, L., Rodgers, M., y Britten, N. (2006). Guidance on the conduct of narrative synthesis in systematic reviews. ESRC Methods Programme.
Rosales-Ricardo, Y., y Cáceres-Manzano, V. (2024). Effects of physical exercise on academic performance in university students: A systematic review. Health Professions Education, 10, 174-184. https://doi.org/10.55890/2452-3011.1174
Sánchez-Meca, J. (2010). Cómo realizar una revisión sistemática y un meta-análisis. Aula Abierta, 38(2), 53-64.
Sánchez-Meca, J. (2022). Revisiones sistemáticas y meta-análisis en Educación: Un tutorial. Revista Interuniversitaria de Investigación en Tecnologías Educativas,13, 5-40. https://doi.org/10.6018/riite.545451
Sánchez-Meca, J., y Ato, M. (1989). Meta-análisis: Una alternativa metodológica a las revisiones tradicionales de la investigación. En J. Arnau, y H. Carpintero (Eds.), Tratado de psicología general I: Historia, teoría y método (pp. 617-669). Alhambra.
Sánchez-Meca, J., Marín-Martínez, F., y López-López, J. A. (2011). Meta-análisis e intervención psicosocial basada en la evidencia. Psychosocial Intervention, 20, 95-107. https://doi.org/10.5093/in2011v20n1a9
Siddaway, A. P., Wood, A. M., y Hedges, L. V. (2019). How to do a systematic review: A best practice guide for conducting and reporting narrative reviews, meta-analyses, and meta-syntheses. Annual Review of Psychology, 70, 747-770. https://doi.org/10.1146/annurev-psych-010418-102803
Sterne, J. A. C., Hernán, M. A., McAleenan, A., Reeves, B. C., y Higgins, J. P. T. (2024). Chapter 25: Assessing risk of bias in a non-randomized study. En J. P. T. Higgins, J. Thomas, J. Chandler, M. Cumpston, T. Li, M. J. Page, y V. A. Welch (Eds.), Cochrane handbook for systematic reviews of interventions (Vers. 6.5). Cochrane. www.cochrane.org/handbook.
Thomson, H. J., y Thomas, S. (2013). The effect direction plot: visual display of non-standardised effects across multiple outcome domains. Research Synthesis Methods, 4, 95-101. https://doi.org/10.1002/jrsm.1060
Wells, G. A., Shea, B., O’Connell, D., Peterson, J., Welch, V., Losos, M., y Tugwell, P. (2000). The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. https://ohri.ca/en/who-we-are/core-facilities-and-platforms/ottawa-methods-centre/newcastle-ottawa-scale

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2026 Aula Abierta

